PT-141 10mg

PT-141, also known as Bremelanotide, is a synthetic melanocortin peptide used in research settings. It is a non-selective agonist of melanocortin receptors (MC1R and MC4R) and is being investigated for its potential role in addressing issues related to sexual arousal in various research models.

Mechanism of Action

PT-141's mechanism of action involves the activation of melanocortin receptors, particularly MC4R, which are found in the central nervous system. Activation of these receptors is thought to influence neural pathways associated with sexual arousal and desire. This central action distinguishes PT-141 from other treatments that primarily act on the vascular system.

Structure and Class

PT-141 is a synthetic peptide derived from alpha-melanocyte-stimulating hormone (alpha-MSH). It is a cyclic heptapeptide with the amino acid sequence Ac-Nle-cyclo[-Asp-His-D-Phe-Arg-Trp-Lys]-OH. As a melanocortin receptor agonist, it belongs to a class of compounds that modulate the melanocortin system, a complex network involved in diverse physiological functions including energy homeostasis, inflammation, and sexual behavior.

Primary Research Areas

The primary research area for PT-141 focuses on its effects on sexual function in both male and female research models. Researchers are exploring its potential to modulate various aspects of sexual response, including arousal and desire. Studies often investigate its central nervous system effects due to its mechanism of action.

Notable Peer-Reviewed Findings

Research suggests that PT-141 can induce pro-sexual effects in various animal models, including rodents and primates. Studies have observed changes in sexual behavior markers following administration. Further investigations are ongoing to fully understand its pharmacological profile and potential applications within controlled research environments.