Melanotan I (MT1) 10mg

Research-grade Melanotan I (Nle4-D-Phe7-α-MSH / afamelanotide), 10mg lyophilized vial. For laboratory use only.

SKU: MELANOTAN_I_10MG
Form: Lyophilized powder
Contents: 10 mg / vial
Purity: ≥99%

Storage: lyophilized −20°C · reconstituted 2–8°C, protect from light

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Price

$29.95

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Lot-matched COA

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Mechanism of Action

Melanotan I (MT1, also known as afamelanotide / Nle4-D-Phe7-alpha-MSH) is a synthetic analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that binds melanocortin-1 receptors (MC1R) on melanocytes. MC1R activation increases intracellular cAMP and upregulates eumelanin synthesis via the MITF/tyrosinase pathway.

Structure and Class

A 13-amino-acid linear melanocortin peptide derived from alpha-MSH, modified with norleucine at position 4 and D-phenylalanine at position 7 to confer enhanced receptor affinity and metabolic stability versus native alpha-MSH. Class: melanocortin receptor agonist.

Primary Research Areas

Investigated in melanogenesis, photoprotection (erythropoietic protoporphyria), MC1R signaling, and pigmentary disorder models. Unlike Melanotan II, MT1 is more selective for MC1R and lacks the broader melanocortin receptor activity associated with MT2.

Notable Peer-Reviewed Findings

Levine et al. and subsequent investigators characterized MT1's MC1R-mediated melanogenic activity. Afamelanotide is approved in the EU and US for adult patients with erythropoietic protoporphyria, where clinical trials demonstrated reduced phototoxic reactions. Reference: peptidedosages.com does not currently publish an MT1-specific protocol; this monograph will be updated when one is available.

Cosmetic Research

Cosmetic research applications

Studied in skin, hair, and pigment-cell models for effects on melanogenesis, collagen synthesis, and dermal repair.

Melanocyte activity and MC1R/MC4R receptor pathway studies
Fibroblast collagen-I/III and elastin expression assays
UV-damage and photoaging protective endpoints in 3D skin models
Hair-follicle dermal-papilla and pigment-research protocols

For laboratory research use only · not for human or veterinary use

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For laboratory research use only. Not for human or veterinary consumption. Not for diagnostic, therapeutic, or any in vivo use. Buyer assumes all responsibility and risk of use.

Melanotan I (MT1) 10mg

10mg · $29.95